nigel.stanger / Digital_Repository
Transfer to URL with SHA Find file
Newer
Older
Digital_Repository / Misc / Mass downloads / UTas / 943.html
Nigel Stanger on 7 May 2013 25 KB - Imported Misc directory.
Raw Blame History 
  1. <!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN"
  2. "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
  3. <html>
  4.   <head>
  5.     <title>UTas ePrints - The Genetic Contribution and Relevance of Knee Cartilage Defects: Case-Control and Sib-Pair Studies</title>
  6.     <script type="text/javascript" src="http://eprints.utas.edu.au/javascript/auto.js"><!-- padder --></script>
  7.     <style type="text/css" media="screen">@import url(http://eprints.utas.edu.au/style/auto.css);</style>
  8.     <style type="text/css" media="print">@import url(http://eprints.utas.edu.au/style/print.css);</style>
  9.     <link rel="icon" href="/images/eprints/favicon.ico" type="image/x-icon" />
  10.     <link rel="shortcut icon" href="/images/eprints/favicon.ico" type="image/x-icon" />
  11.     <link rel="Top" href="http://eprints.utas.edu.au/" />
  12.     <link rel="Search" href="http://eprints.utas.edu.au/cgi/search" />
  13.     <meta content="Ding, Changhai" name="eprints.creators_name" />
  14. <meta content="Cicuttini, Flavia" name="eprints.creators_name" />
  15. <meta content="Scott, Fiona" name="eprints.creators_name" />
  16. <meta content="Stankovich, James" name="eprints.creators_name" />
  17. <meta content="Cooley, Helen" name="eprints.creators_name" />
  18. <meta content="Jones, Graeme" name="eprints.creators_name" />
  19. <meta content="chding@utas.edu.au" name="eprints.creators_id" />
  20. <meta content="" name="eprints.creators_id" />
  21. <meta content="" name="eprints.creators_id" />
  22. <meta content="" name="eprints.creators_id" />
  23. <meta content="" name="eprints.creators_id" />
  24. <meta content="" name="eprints.creators_id" />
  25. <meta content="article" name="eprints.type" />
  26. <meta content="2007-05-03" name="eprints.datestamp" />
  27. <meta content="2008-01-08 15:30:00" name="eprints.lastmod" />
  28. <meta content="show" name="eprints.metadata_visibility" />
  29. <meta content="The Genetic Contribution and Relevance of Knee Cartilage Defects: Case-Control and Sib-Pair Studies 
  30.  
  31. " name="eprints.title" />
  32. <meta content="pub" name="eprints.ispublished" />
  33. <meta content="321028" name="eprints.subjects" />
  34. <meta content="restricted" name="eprints.full_text_status" />
  35. <meta content="knee, cartilage defects, osteoarthritis, genetics, heritability" name="eprints.keywords" />
  36. <meta content="Table of contents of issue at: http://jrheum.com/archives/oct05.html" name="eprints.note" />
  37. <meta content="Objective. To describe the differences in knee cartilage defects between offspring of subjects with at least one parent with a total knee replacement for severe primary knee osteoarthritis (OA) and controls; and to estimate the heritability of knee cartilage defects in sib-pairs. 
  38.  
  39. Methods. Population based, case-control study of 186 matched pairs (mean age 45 yrs, range 26-61) and sib-pair study of 128 subjects from 51 families (115 sib-pairs) within the case-control study. Knee cartilage defect scores (0-4) and prevalence (a cartilage defect score >= 2) were assessed at the patellar, tibial, and femoral sites by processing images acquired using T1 weighted fat-saturated magnetic resonance imaging. Heritability was estimated using the SOLAR genetic analysis program. 
  40.  
  41. Results. The prevalence of knee cartilage defects was surprisingly high (50% scored >= 2 in any site). Compared to controls, offspring had higher knee cartilage defect scores and prevalence in tibiofemoral (4.39 vs 4.01, p = 0.003; 41% vs 28%, p = 0.009), patellar (1.32 vs 1.10, p = 0.031; 35% vs 26%, p = 0.075), and whole (5.71 vs 5.10, p = 0.002; 57% vs 42%, p = 0.007) compartments. These all became nonsignificant after adjustment for knee pain and radiographic OA. In the sib-pair component, knee cartilage defects had heritability for scores and prevalence, respectively, of 38% (p = 0.072) and 47% (p = 0.082) for tibiofemoral, 52% (p = 0.009) and 78% (p = 0.025) for patellar, and 43% (p = 0.038) and 68% (p = 0.072) for the whole compartments. These estimates became weaker at tibiofemoral and whole compartments after adjustment for bone size, knee pain, and radiographic OA.
  42. " name="eprints.abstract" />
  43. <meta content="2005-10-01" name="eprints.date" />
  44. <meta content="published" name="eprints.date_type" />
  45. <meta content="Journal of Rheumatology" name="eprints.publication" />
  46. <meta content="32" name="eprints.volume" />
  47. <meta content="10" name="eprints.number" />
  48. <meta content="1937-1942" name="eprints.pagerange" />
  49. <meta content="UNSPECIFIED" name="eprints.thesis_type" />
  50. <meta content="TRUE" name="eprints.refereed" />
  51. <meta content="1499-2752" name="eprints.issn" />
  52. <meta content="http://www.jrheum.com/subscribers/05/10/1937.html" name="eprints.official_url" />
  53. <meta content="Ding, Changhai and Cicuttini, Flavia and Scott, Fiona and Stankovich, James and Cooley, Helen and Jones, Graeme (2005) The Genetic Contribution and Relevance of Knee Cartilage Defects: Case-Control and Sib-Pair Studies. Journal of Rheumatology, 32 (10). pp. 1937-1942. ISSN 1499-2752" name="eprints.citation" />
  54. <meta content="http://eprints.utas.edu.au/943/1/J_Rheumatol.pdf" name="eprints.document_url" />
  55. <link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" />
  56. <meta content="The Genetic Contribution and Relevance of Knee Cartilage Defects: Case-Control and Sib-Pair Studies 
  57.  
  58. " name="DC.title" />
  59. <meta content="Ding, Changhai" name="DC.creator" />
  60. <meta content="Cicuttini, Flavia" name="DC.creator" />
  61. <meta content="Scott, Fiona" name="DC.creator" />
  62. <meta content="Stankovich, James" name="DC.creator" />
  63. <meta content="Cooley, Helen" name="DC.creator" />
  64. <meta content="Jones, Graeme" name="DC.creator" />
  65. <meta content="321028 Rheumatology and Arthritis" name="DC.subject" />
  66. <meta content="Objective. To describe the differences in knee cartilage defects between offspring of subjects with at least one parent with a total knee replacement for severe primary knee osteoarthritis (OA) and controls; and to estimate the heritability of knee cartilage defects in sib-pairs. 
  67.  
  68. Methods. Population based, case-control study of 186 matched pairs (mean age 45 yrs, range 26-61) and sib-pair study of 128 subjects from 51 families (115 sib-pairs) within the case-control study. Knee cartilage defect scores (0-4) and prevalence (a cartilage defect score >= 2) were assessed at the patellar, tibial, and femoral sites by processing images acquired using T1 weighted fat-saturated magnetic resonance imaging. Heritability was estimated using the SOLAR genetic analysis program. 
  69.  
  70. Results. The prevalence of knee cartilage defects was surprisingly high (50% scored >= 2 in any site). Compared to controls, offspring had higher knee cartilage defect scores and prevalence in tibiofemoral (4.39 vs 4.01, p = 0.003; 41% vs 28%, p = 0.009), patellar (1.32 vs 1.10, p = 0.031; 35% vs 26%, p = 0.075), and whole (5.71 vs 5.10, p = 0.002; 57% vs 42%, p = 0.007) compartments. These all became nonsignificant after adjustment for knee pain and radiographic OA. In the sib-pair component, knee cartilage defects had heritability for scores and prevalence, respectively, of 38% (p = 0.072) and 47% (p = 0.082) for tibiofemoral, 52% (p = 0.009) and 78% (p = 0.025) for patellar, and 43% (p = 0.038) and 68% (p = 0.072) for the whole compartments. These estimates became weaker at tibiofemoral and whole compartments after adjustment for bone size, knee pain, and radiographic OA.
  71. " name="DC.description" />
  72. <meta content="2005-10-01" name="DC.date" />
  73. <meta content="Article" name="DC.type" />
  74. <meta content="PeerReviewed" name="DC.type" />
  75. <meta content="application/pdf" name="DC.format" />
  76. <meta content="http://eprints.utas.edu.au/943/1/J_Rheumatol.pdf" name="DC.identifier" />
  77. <meta content="http://www.jrheum.com/subscribers/05/10/1937.html" name="DC.relation" />
  78. <meta content="Ding, Changhai and Cicuttini, Flavia and Scott, Fiona and Stankovich, James and Cooley, Helen and Jones, Graeme (2005) The Genetic Contribution and Relevance of Knee Cartilage Defects: Case-Control and Sib-Pair Studies. Journal of Rheumatology, 32 (10). pp. 1937-1942. ISSN 1499-2752" name="DC.identifier" />
  79. <meta content="http://eprints.utas.edu.au/943/" name="DC.relation" />
  80. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/BibTeX/epprod-eprint-943.bib" title="BibTeX" type="text/plain" />
  81. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/ContextObject/epprod-eprint-943.xml" title="OpenURL ContextObject" type="text/xml" />
  82. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/ContextObject::Dissertation/epprod-eprint-943.xml" title="OpenURL Dissertation" type="text/xml" />
  83. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/ContextObject::Journal/epprod-eprint-943.xml" title="OpenURL Journal" type="text/xml" />
  84. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/DC/epprod-eprint-943.txt" title="Dublin Core" type="text/plain" />
  85. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/DIDL/epprod-eprint-943.xml" title="DIDL" type="text/xml" />
  86. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/EndNote/epprod-eprint-943.enw" title="EndNote" type="text/plain" />
  87. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/HTML/epprod-eprint-943.html" title="HTML Citation" type="text/html; charset=utf-8" />
  88. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/METS/epprod-eprint-943.xml" title="METS" type="text/xml" />
  89. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/MODS/epprod-eprint-943.xml" title="MODS" type="text/xml" />
  90. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/RIS/epprod-eprint-943.ris" title="Reference Manager" type="text/plain" />
  91. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/Refer/epprod-eprint-943.refer" title="Refer" type="text/plain" />
  92. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/Simple/epprod-eprint-943text" title="Simple Metadata" type="text/plain" />
  93. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/Text/epprod-eprint-943.txt" title="ASCII Citation" type="text/plain; charset=utf-8" />
  94. <link rel="alternate" href="http://eprints.utas.edu.au/cgi/export/943/XML/epprod-eprint-943.xml" title="EP3 XML" type="text/xml" />
  95.  
  96.   </head>
  97.   <body bgcolor="#ffffff" text="#000000" onLoad="loadRoutine(); MM_preloadImages('images/eprints/ePrints_banner_r5_c5_f2.gif','images/eprints/ePrints_banner_r5_c7_f2.gif','images/eprints/ePrints_banner_r5_c8_f2.gif','images/eprints/ePrints_banner_r5_c9_f2.gif','images/eprints/ePrints_banner_r5_c10_f2.gif','images/eprints/ePrints_banner_r5_c11_f2.gif','images/eprints/ePrints_banner_r6_c4_f2.gif')">
  98.     
  99.     <div class="ep_noprint"><noscript><style type="text/css">@import url(http://eprints.utas.edu.au/style/nojs.css);</style></noscript></div>
  100.  
  101.  
  102.  
  103.  
  104. <table width="795" border="0" cellspacing="0" cellpadding="0">
  105.   <tr>
  106.     <td><script language="JavaScript1.2">mmLoadMenus();</script>
  107.       <table border="0" cellpadding="0" cellspacing="0" width="795">
  108.         <!-- fwtable fwsrc="eprints_banner_final2.png" fwbase="ePrints_banner.gif" fwstyle="Dreamweaver" fwdocid = "1249563342" fwnested="0" -->
  109.         <tr>
  110.           <td><img src="/images/eprints/spacer.gif" width="32" height="1" border="0" alt="" /></td>
  111.           <td><img src="/images/eprints/spacer.gif" width="104" height="1" border="0" alt="" /></td>
  112.           <td><img src="/images/eprints/spacer.gif" width="44" height="1" border="0" alt="" /></td>
  113.           <td><img src="/images/eprints/spacer.gif" width="105" height="1" border="0" alt="" /></td>
  114.           <td><img src="/images/eprints/spacer.gif" width="41" height="1" border="0" alt="" /></td>
  115.           <td><img src="/images/eprints/spacer.gif" width="16" height="1" border="0" alt="" /></td>
  116.           <td><img src="/images/eprints/spacer.gif" width="68" height="1" border="0" alt="" /></td>
  117.           <td><img src="/images/eprints/spacer.gif" width="68" height="1" border="0" alt="" /></td>
  118.           <td><img src="/images/eprints/spacer.gif" width="68" height="1" border="0" alt="" /></td>
  119.           <td><img src="/images/eprints/spacer.gif" width="82" height="1" border="0" alt="" /></td>
  120.           <td><img src="/images/eprints/spacer.gif" width="69" height="1" border="0" alt="" /></td>
  121.           <td><img src="/images/eprints/spacer.gif" width="98" height="1" border="0" alt="" /></td>
  122.           <td><img src="/images/eprints/spacer.gif" width="1" height="1" border="0" alt="" /></td>
  123.         </tr>
  124.         <tr>
  125.           <td colspan="12"><img name="ePrints_banner_r1_c1" src="/images/eprints/ePrints_banner_r1_c1.gif" width="795" height="10" border="0" alt="" /></td>
  126.           <td><img src="/images/eprints/spacer.gif" width="1" height="10" border="0" alt="" /></td>
  127.         </tr>
  128.         <tr>
  129.           <td rowspan="6"><img name="ePrints_banner_r2_c1" src="/images/eprints/ePrints_banner_r2_c1.gif" width="32" height="118" border="0" alt="" /></td>
  130.           <td rowspan="5"><a href="http://www.utas.edu.au/"><img name="ePrints_banner_r2_c2" src="/images/eprints/ePrints_banner_r2_c2.gif" width="104" height="103" border="0" alt="" /></a></td>
  131.           <td colspan="10"><img name="ePrints_banner_r2_c3" src="/images/eprints/ePrints_banner_r2_c3.gif" width="659" height="41" border="0" alt="" /></td>
  132.           <td><img src="/images/eprints/spacer.gif" width="1" height="41" border="0" alt="" /></td>
  133.         </tr>
  134.         <tr>
  135.           <td colspan="3"><a href="http://eprints.utas.edu.au/"><img name="ePrints_banner_r3_c3" src="/images/eprints/ePrints_banner_r3_c3.gif" width="190" height="31" border="0" alt="" /></a></td>
  136.           <td rowspan="2" colspan="7"><img name="ePrints_banner_r3_c6" src="/images/eprints/ePrints_banner_r3_c6.gif" width="469" height="37" border="0" alt="" /></td>
  137.           <td><img src="/images/eprints/spacer.gif" width="1" height="31" border="0" alt="" /></td>
  138.         </tr>
  139.         <tr>
  140.           <td colspan="3"><img name="ePrints_banner_r4_c3" src="/images/eprints/ePrints_banner_r4_c3.gif" width="190" height="6" border="0" alt="" /></td>
  141.           <td><img src="/images/eprints/spacer.gif" width="1" height="6" border="0" alt="" /></td>
  142.         </tr>
  143.         <tr>
  144.           <td colspan="2"><img name="ePrints_banner_r5_c3" src="/images/eprints/ePrints_banner_r5_c3.gif" width="149" height="1" border="0" alt="" /></td>
  145.           <td rowspan="2" colspan="2"><a href="/information.html" onMouseOut="MM_swapImgRestore();MM_startTimeout()" onMouseOver="MM_showMenu(window.mm_menu_0821132634_0,0,25,null,'ePrints_banner_r5_c5');MM_swapImage('ePrints_banner_r5_c5','','/images/eprints/ePrints_banner_r5_c5_f2.gif',1);"><img name="ePrints_banner_r5_c5" src="/images/eprints/ePrints_banner_r5_c5.gif" width="57" height="25" border="0" alt="About" /></a></td>
  146.           <td rowspan="2"><a href="/view/" onMouseOut="MM_swapImgRestore();MM_startTimeout()" onMouseOver="MM_showMenu(window.mm_menu_0821133021_1,0,25,null,'ePrints_banner_r5_c7');MM_swapImage('ePrints_banner_r5_c7','','/images/eprints/ePrints_banner_r5_c7_f2.gif',1);"><img name="ePrints_banner_r5_c7" src="/images/eprints/ePrints_banner_r5_c7.gif" width="68" height="25" border="0" alt="Browse" /></a></td>
  147.           <td rowspan="2"><a href="/perl/search/simple" onMouseOut="MM_swapImgRestore();MM_startTimeout()" onMouseOver="MM_showMenu(window.mm_menu_0821133201_2,0,25,null,'ePrints_banner_r5_c8');MM_swapImage('ePrints_banner_r5_c8','','/images/eprints/ePrints_banner_r5_c8_f2.gif',1);"><img name="ePrints_banner_r5_c8" src="/images/eprints/ePrints_banner_r5_c8.gif" width="68" height="25" border="0" alt="Search" /></a></td>
  148.           <td rowspan="2"><a href="/perl/register" onMouseOut="MM_swapImgRestore();MM_startTimeout();" onMouseOver="MM_showMenu(window.mm_menu_1018171924_3,0,25,null,'ePrints_banner_r5_c9');MM_swapImage('ePrints_banner_r5_c9','','/images/eprints/ePrints_banner_r5_c9_f2.gif',1);"><img name="ePrints_banner_r5_c9" src="/images/eprints/ePrints_banner_r5_c9.gif" width="68" height="25" border="0" alt="register" /></a></td>
  149.           <td rowspan="2"><a href="/perl/users/home" onMouseOut="MM_swapImgRestore();MM_startTimeout()" onMouseOver="MM_showMenu(window.mm_menu_0821133422_4,0,25,null,'ePrints_banner_r5_c10');MM_swapImage('ePrints_banner_r5_c10','','/images/eprints/ePrints_banner_r5_c10_f2.gif',1);"><img name="ePrints_banner_r5_c10" src="/images/eprints/ePrints_banner_r5_c10.gif" width="82" height="25" border="0" alt="user area" /></a></td>
  150.           <td rowspan="2"><a href="/help/" onMouseOut="MM_swapImgRestore();MM_startTimeout()" onMouseOver="MM_showMenu(window.mm_menu_0821133514_5,0,25,null,'ePrints_banner_r5_c11');MM_swapImage('ePrints_banner_r5_c11','','/images/eprints/ePrints_banner_r5_c11_f2.gif',1);"><img name="ePrints_banner_r5_c11" src="/images/eprints/ePrints_banner_r5_c11.gif" width="69" height="25" border="0" alt="Help" /></a></td>
  151.           <td rowspan="3" colspan="4"><img name="ePrints_banner_r5_c12" src="/images/eprints/ePrints_banner_r5_c12.gif" width="98" height="40" border="0" alt="" /></td>
  152.           <td><img src="/images/eprints/spacer.gif" width="1" height="1" border="0" alt="" /></td>
  153.         </tr>
  154.         <tr>
  155.           <td rowspan="2"><img name="ePrints_banner_r6_c3" src="/images/eprints/ePrints_banner_r6_c3.gif" width="44" height="39" border="0" alt="ePrints home" /></td>
  156.           <td><a href="/" onMouseOut="MM_swapImgRestore()" onMouseOver="MM_swapImage('ePrints_banner_r6_c4','','/images/eprints/ePrints_banner_r6_c4_f2.gif',1);"><img name="ePrints_banner_r6_c4" src="/images/eprints/ePrints_banner_r6_c4.gif" width="105" height="24" border="0" alt="ePrints home" /></a></td>
  157.           <td><img src="/images/eprints/spacer.gif" width="1" height="24" border="0" alt="" /></td>
  158.         </tr>
  159.         <tr>
  160.           <td><img name="ePrints_banner_r7_c2" src="/images/eprints/ePrints_banner_r7_c2.gif" width="104" height="15" border="0" alt="" /></td>
  161.           <td colspan="8"><img name="ePrints_banner_r7_c4" src="/images/eprints/ePrints_banner_r7_c4.gif" width="517" height="15" border="0" alt="" /></td>
  162.           <td><img src="/images/eprints/spacer.gif" width="1" height="15" border="0" alt="" /></td>
  163.         </tr>
  164.       </table></td>
  165.   </tr>
  166.     <tr><td><table width="100%" style="font-size: 90%; border: solid 1px #ccc; padding: 3px"><tr>
  167.       <td align="left"><a href="http://eprints.utas.edu.au/cgi/users/home">Login</a> | <a href="http://eprints.utas.edu.au/cgi/register">Create Account</a></td>
  168.       <td align="right" style="white-space: nowrap">
  169.         <form method="get" accept-charset="utf-8" action="http://eprints.utas.edu.au/cgi/search" style="display:inline">
  170.           <input class="ep_tm_searchbarbox" size="20" type="text" name="q" />
  171.           <input class="ep_tm_searchbarbutton" value="Search" type="submit" name="_action_search" />
  172.           <input type="hidden" name="_order" value="bytitle" />
  173.           <input type="hidden" name="basic_srchtype" value="ALL" />
  174.           <input type="hidden" name="_satisfyall" value="ALL" />
  175.         </form>
  176.       </td>
  177.     </tr></table></td></tr>
  178.   <tr>
  179.     <td class="toplinks"><!-- InstanceBeginEditable name="content" -->
  180.  
  181.  
  182. <div align="center">
  183.   
  184.   <table width="720" class="ep_tm_main"><tr><td align="left">
  185.     <h1 class="ep_tm_pagetitle">The Genetic Contribution and Relevance of Knee Cartilage Defects: Case-Control and Sib-Pair Studies</h1>
  186.     <p style="margin-bottom: 1em" class="not_ep_block"><span class="person_name">Ding, Changhai</span> and <span class="person_name">Cicuttini, Flavia</span> and <span class="person_name">Scott, Fiona</span> and <span class="person_name">Stankovich, James</span> and <span class="person_name">Cooley, Helen</span> and <span class="person_name">Jones, Graeme</span> (2005) <xhtml:em>The Genetic Contribution and Relevance of Knee Cartilage Defects: Case-Control and Sib-Pair Studies.</xhtml:em> Journal of Rheumatology, 32 (10). pp. 1937-1942. ISSN 1499-2752</p><p style="margin-bottom: 1em" class="not_ep_block"></p><table style="margin-bottom: 1em" class="not_ep_block"><tr><td valign="top" style="text-align:center"><a href="http://eprints.utas.edu.au/943/1/J_Rheumatol.pdf"><img alt="[img]" src="http://eprints.utas.edu.au/style/images/fileicons/application_pdf.png" class="ep_doc_icon" border="0" /></a></td><td valign="top"><a href="http://eprints.utas.edu.au/943/1/J_Rheumatol.pdf"><span class="ep_document_citation">PDF</span></a> - Full text restricted - Requires a PDF viewer<br />657Kb</td></tr></table><p style="margin-bottom: 1em" class="not_ep_block">Official URL: <a href="http://www.jrheum.com/subscribers/05/10/1937.html">http://www.jrheum.com/subscribers/05/10/1937.html</a></p><div class="not_ep_block"><h2>Abstract</h2><p style="padding-bottom: 16px; text-align: left; margin: 1em auto 0em auto">Objective. To describe the differences in knee cartilage defects between offspring of subjects with at least one parent with a total knee replacement for severe primary knee osteoarthritis (OA) and controls; and to estimate the heritability of knee cartilage defects in sib-pairs. 
  187.  
  188. Methods. Population based, case-control study of 186 matched pairs (mean age 45 yrs, range 26-61) and sib-pair study of 128 subjects from 51 families (115 sib-pairs) within the case-control study. Knee cartilage defect scores (0-4) and prevalence (a cartilage defect score &gt;= 2) were assessed at the patellar, tibial, and femoral sites by processing images acquired using T1 weighted fat-saturated magnetic resonance imaging. Heritability was estimated using the SOLAR genetic analysis program. 
  189.  
  190. Results. The prevalence of knee cartilage defects was surprisingly high (50% scored &gt;= 2 in any site). Compared to controls, offspring had higher knee cartilage defect scores and prevalence in tibiofemoral (4.39 vs 4.01, p = 0.003; 41% vs 28%, p = 0.009), patellar (1.32 vs 1.10, p = 0.031; 35% vs 26%, p = 0.075), and whole (5.71 vs 5.10, p = 0.002; 57% vs 42%, p = 0.007) compartments. These all became nonsignificant after adjustment for knee pain and radiographic OA. In the sib-pair component, knee cartilage defects had heritability for scores and prevalence, respectively, of 38% (p = 0.072) and 47% (p = 0.082) for tibiofemoral, 52% (p = 0.009) and 78% (p = 0.025) for patellar, and 43% (p = 0.038) and 68% (p = 0.072) for the whole compartments. These estimates became weaker at tibiofemoral and whole compartments after adjustment for bone size, knee pain, and radiographic OA.
  191. </p></div><table style="margin-bottom: 1em" cellpadding="3" class="not_ep_block" border="0"><tr><th valign="top" class="ep_row">Item Type:</th><td valign="top" class="ep_row">Article</td></tr><tr><th valign="top" class="ep_row">Additional Information:</th><td valign="top" class="ep_row">Table of contents of issue at: http://jrheum.com/archives/oct05.html</td></tr><tr><th valign="top" class="ep_row">Keywords:</th><td valign="top" class="ep_row">knee, cartilage defects, osteoarthritis, genetics, heritability</td></tr><tr><th valign="top" class="ep_row">Subjects:</th><td valign="top" class="ep_row"><a href="http://eprints.utas.edu.au/view/subjects/321028.html">320000 Medical and Health Sciences &gt; 321000 Clinical Sciences &gt; 321028 Rheumatology and Arthritis</a></td></tr><tr><th valign="top" class="ep_row">ID Code:</th><td valign="top" class="ep_row">943</td></tr><tr><th valign="top" class="ep_row">Deposited By:</th><td valign="top" class="ep_row"><span class="ep_name_citation"><span class="person_name">Dr Changhai / C Ding</span></span></td></tr><tr><th valign="top" class="ep_row">Deposited On:</th><td valign="top" class="ep_row">03 May 2007</td></tr><tr><th valign="top" class="ep_row">Last Modified:</th><td valign="top" class="ep_row">09 Jan 2008 02:30</td></tr><tr><th valign="top" class="ep_row">ePrint Statistics:</th><td valign="top" class="ep_row"><a target="ePrintStats" href="/es/index.php?action=show_detail_eprint;id=943;">View statistics for this ePrint</a></td></tr></table><p align="right">Repository Staff Only: <a href="http://eprints.utas.edu.au/cgi/users/home?screen=EPrint::View&amp;eprintid=943">item control page</a></p>
  192.   </td></tr></table>
  193. </div>
  194.  
  195.  
  196.  
  197.     <!-- InstanceEndEditable --></td>
  198.   </tr>
  199.   <tr>
  200.     <td><!-- #BeginLibraryItem "/Library/footer_eprints.lbi" -->
  201.     <table width="795" border="0" align="left" cellpadding="0" class="footer">
  202.   <tr valign="top">
  203. <td colspan="2"><div align="center"><a href="http://www.utas.edu.au">UTAS home</a> | <a href="http://www.utas.edu.au/library/">Library home</a> | <a href="/">ePrints home</a> | <a href="/contact.html">contact</a> | <a href="/information.html">about</a> | <a href="/view/">browse</a> | <a href="/perl/search/simple">search</a> | <a href="/perl/register">register</a> | <a href="/perl/users/home">user area</a> | <a href="/help/">help</a></div><br /></td>
  204. </tr>
  205. <tr><td colspan="2"><p><img src="/images/eprints/footerline.gif" width="100%" height="4" /></p></td></tr>
  206.       <tr valign="top">
  207.         <td width="68%" class="footer">Authorised by the University Librarian<br />
  208. © University of Tasmania ABN 30 764 374 782<br />
  209.       <a href="http://www.utas.edu.au/cricos/">CRICOS Provider Code 00586B</a> | <a href="http://www.utas.edu.au/copyright/copyright_disclaimers.html">Copyright &amp; Disclaimers</a> | <a href="http://www.utas.edu.au/accessibility/index.html">Accessibility</a> | <a href="http://eprints.utas.edu.au/feedback/">Site Feedback</a>  </td>
  210.         <td width="32%"><div align="right">
  211.             <p align="right" class="NoPrint"><a href="http://www.utas.edu.au/"><img src="http://www.utas.edu.au/shared/logos/unioftasstrip.gif" alt="University of Tasmania Home Page" width="260" height="16" border="0" align="right" /></a></p>
  212.             <p align="right" class="NoPrint"><a href="http://www.utas.edu.au/"><br />
  213.             </a></p>
  214.         </div></td>
  215.       </tr>
  216.       <tr valign="top">
  217.         <td><p>  </p></td>
  218.         <td><div align="right"><span class="NoPrint"><a href="http://www.eprints.org/software/"><img src="/images/eprintslogo.gif" alt="ePrints logo" width="77" height="29" border="0" align="bottom" /></a></span></div></td>
  219.       </tr>
  220.     </table>
  221.     <!-- #EndLibraryItem -->
  222.     <div align="center"></div></td>
  223.   </tr>
  224. </table>
  225.  
  226.   </body>
  227. </html>